Description

1-Benzyl-1-Tosylmethyl Isocyanide is a versatile and highly reactive organic building block, specifically an isocyanide derivative. Its unique structure makes it a critical reagent in multi-component reactions, enabling the efficient synthesis of complex heterocyclic scaffolds and natural product analogs. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel molecular libraries and active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the Ugi and Passerini multi-component reactions for the rapid generation of drug-like molecules and peptidomimetics.
• Agrochemical Research: Used in the discovery and synthesis of novel pesticides and herbicides with complex heterocyclic cores.
• Material Science: Employed in the development of functional polymers and ligands for catalysis via its reactive isocyanide group.
• Academic & R&D: A fundamental reagent in methodological organic chemistry research for developing new synthetic transformations.
• Chemical Biology: Utilized as a probe or linker in bioconjugation chemistry due to its specific reactivity profile.

Basic Information

Product Name	1-Benzyl-1-Tosylmethyl Isocyanide
CAS No.	58379-86-5
Molecular Formula	C16H15NO2S
Molecular Weight	285.36 g/mol
Synonyms	1-Benzyl-1-[(4-methylphenyl)sulfonyl]methyl isocyanide; Benzyl tosylmethyl isocyanide; BTMI; NSC 334365; Tosylmethyl isocyanide benzyl derivative; α-Isocyano-α-tosyltoluene; (Isocyanomethylsulfonyl)(phenyl)methane, 4-methylbenzene derivative
EINECS	Contact for details

Quality Control

Our 1-Benzyl-1-Tosylmethyl Isocyanide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccant in the storage area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.