Description

1-n-Butyl-1-Tosylmethyl Isocyanide is a specialized organic building block featuring both an isocyanide and a tosylmethyl functional group. This unique bifunctional structure makes it a valuable reagent in advanced organic synthesis, particularly for constructing complex heterocyclic frameworks. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex nitrogen-containing heterocycles, which are core structures in many drug candidates.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, leveraging its reactivity to create new molecular scaffolds.
• Multicomponent Reaction (MCR) Chemistry: Serves as a critical component in Passerini and Ugi-type reactions for the efficient, one-pot generation of diverse compound libraries.
• Ligand Synthesis: Employed in the preparation of specialized isocyanide-based ligands for catalysis and material science applications.
• Peptidomimetics & Macrocycle Construction: Facilitates the synthesis of peptide analogs and constrained macrocyclic compounds for biological evaluation.
• Academic & Industrial R&D: A versatile tool for methodological development and exploring new synthetic pathways in organic chemistry laboratories.

Basic Information

Product Name	1-n-Butyl-1-Tosylmethyl Isocyanide
CAS No.	58379-83-2
Molecular Formula	C₁₃H₁₇NO₂S
Molecular Weight	251.34 g/mol
Synonyms	1-Butyl-1-[(4-methylphenyl)sulfonyl]methyl isocyanide; 1-Butyl-1-(p-tolylsulfonyl)methyl isocyanide; Tosylmethyl isocyanide, N-butyl derivative; 1-Isocyano-1-(p-toluenesulfonylmethyl)butane; BTMI; 1-n-Butyl-1-(p-toluenesulfonyl)methyl isocyanide; 1-Butyl-1-(tosylmethyl)isocyanide
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. Each batch is characterized by modern analytical techniques to confirm identity and purity, providing consistency critical for synthetic applications. Certificates of Analysis (COA) detailing specific batch results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is easily oxidized and highly volatile; it is recommended to store under an inert atmosphere such as nitrogen or argon for long-term stability and to minimize decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.