Description

1-n-Propyl-1-Tosylmethyl Isocyanide is a specialized organic building block featuring a reactive isocyanide group protected by a tosylmethyl moiety. This compound is valued for its role as a versatile intermediate in multi-component reactions, enabling the efficient synthesis of complex heterocyclic and peptidomimetic structures. It is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for lead optimization and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key reagent in the Ugi and Passerini multi-component reactions for the rapid assembly of diverse compound libraries and complex molecular scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific heterocyclic cores.
• Material Science Research: Employed in the synthesis of functionalized polymers and ligands for catalytic systems.
• Academic & Discovery Chemistry: Serves as a valuable building block in medicinal chemistry programs and methodology development within R&D laboratories.
• Peptidomimetics: Facilitates the creation of isocyanide-derived peptide analogs with potential therapeutic applications.

Basic Information

Product Name	1-n-Propyl-1-Tosylmethyl Isocyanide
CAS No.	58379-82-1
Molecular Formula	C12H15NO2S
Molecular Weight	237.32 g/mol
Synonyms	1-Isocyano-1-tosylpropane; 1-Tosylmethyl-1-propyl isocyanide; (Tosylmethyl)propyl isocyanide; Propyl(tosylmethyl) isocyanide; 1-Propyl-1-[(4-methylphenyl)sulfonyl]methyl isocyanide; TosMIC Propyl Derivative; 1-n-Propyl-1-(p-tolylsulfonyl)methyl isocyanide
EINECS	Contact for details

Quality Control

Our 1-n-Propyl-1-Tosylmethyl Isocyanide is produced under strict quality management protocols. Each batch is characterized and tested to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing results from analytical methods including HPLC, NMR, and IR spectroscopy. We support cGMP-compliant manufacturing for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use and stored away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.