Description

1-Ethyl-1-Tosylmethyl Isocyanide is a specialized organic building block featuring a reactive isocyanide functional group adjacent to a tosyl-protected methylene unit. This compound matters for its versatility as a key intermediate in multi-component reactions, enabling the efficient synthesis of complex heterocyclic scaffolds and natural product analogs. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for lead optimization and the discovery of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of nitrogen-containing heterocycles via Passerini and Ugi multi-component reactions for drug discovery.
• Agrochemical Research: Used in the development of novel pesticides and herbicides by constructing complex molecular architectures.
• Material Science: Serves as a building block for functional polymers and ligands with tailored properties.
• Academic & Contract Research: Essential for methodological development in organic synthesis and catalysis studies.
• Peptidomimetics Synthesis: Facilitates the creation of peptide analogs and macrocycles for biochemical probes.

Basic Information

Product Name	1-Ethyl-1-Tosylmethyl Isocyanide
CAS No.	58379-81-0
Molecular Formula	C11H13NO2S
Molecular Weight	223.29 g/mol
Synonyms	1-Ethyl-1-[(4-methylphenyl)sulfonyl]methyl isocyanide; 1-Ethyl-1-(p-tolylsulfonyl)methyl isocyanide; Tosylmethyl isocyanide, 1-ethyl derivative; 1-Isocyano-1-(p-toluenesulfonyl)ethane; 1-Ethyl-1-(tosylmethyl)isocyanide; (1-Isocyanoethyl)(p-tolyl)sulfonylmethane; TOSMIC, 1-ethyl analog; p-Toluenesulfonylmethyl isocyanide, 1-ethyl homologue
EINECS	Contact for details

Quality Control

Our 1-Ethyl-1-Tosylmethyl Isocyanide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use to prevent evaporation and potential contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.