Description

1-Methyl-1-Tosylmethyl Isocyanide is a versatile and highly reactive organic building block, primarily valued for its role as a key intermediate in multi-component reactions. Its unique structure, featuring both an isocyanide and a tosylmethyl group, makes it an essential reagent for the efficient synthesis of complex heterocycles and functionalized molecules. This compound is particularly sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel molecular scaffolds.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of complex drug candidates, particularly for constructing heterocyclic cores via Passerini and Ugi multi-component reactions.
• Agrochemical Research: Used in the development of novel active ingredients, leveraging its reactivity to create diverse libraries of functionalized compounds for screening.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for the preparation of natural product analogs, dyes, and functional materials.
• Chemical Biology Probe Synthesis: Utilized to create isocyanide-containing probes for studying biological processes and developing new diagnostic tools.

Basic Information

Product Name	1-Methyl-1-Tosylmethyl Isocyanide
CAS No.	58379-80-9
Molecular Formula	C10H11NO2S
Molecular Weight	209.26 g/mol
Synonyms	1-Isocyano-1-methyl-2-(p-tolylsulfonyl)ethane; 1-Methyl-1-[(4-methylphenyl)sulfonyl]methyl isocyanide; Tosylmethyl isocyanide, 1-methyl-; 1-Methyl-1-(p-tolylsulfonyl)methyl isocyanide; 1-Methyl-1-(tosylmethyl)isocyanide; TOSMIC, 1-methyl derivative; (1-Isocyanoethyl)(p-tolylsulfonyl)methane
EINECS	Contact for details

Quality Control

Our 1-Methyl-1-Tosylmethyl Isocyanide is produced under stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to handle and store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.