Description

(3R,4R)-3-[(1,3-Benzodioxole-5-Yl)Methyl]-4-(3,4-Dimethoxybenzyl)-4,5-Dihydrofuran-2(3H)-One is a high-purity, stereochemically defined synthetic intermediate of significant interest in advanced organic synthesis. Its complex molecular architecture, featuring a fused benzodioxole ring and dimethoxybenzyl group, makes it a valuable chiral building block for pharmaceutical research and development. This compound is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel active molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Asymmetric Synthesis: Utilized as a sophisticated starting material or reagent in stereoselective catalytic reactions to introduce complex molecular motifs.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis for lead optimization and discovery.
• Agrochemical Development: Used in the research phase for creating novel, biologically active compounds with potential herbicidal or insecticidal properties.
• Academic & Contract Research: A valuable tool for universities and CROs (Contract Research Organizations) conducting cutting-edge research in synthetic methodology and chemical biology.
• Fine Chemical Production: Acts as a specialized intermediate for the custom synthesis of complex, high-value chemicals for various industrial applications.

Basic Information

Product Name	(3R,4R)-3-[(1,3-Benzodioxole-5-Yl)Methyl]-4-(3,4-Dimethoxybenzyl)-4,5-Dihydrofuran-2(3H)-One
CAS No.	58311-20-9
Molecular Formula	C22H22O6
Molecular Weight	382.41 g/mol
Synonyms	(3R,4R)-3-(1,3-Benzodioxol-5-ylmethyl)-4-(3,4-dimethoxybenzyl)dihydrofuran-2(3H)-one; (3R,4R)-3-(Piperonyl)-4-(3,4-dimethoxybenzyl)-4,5-dihydro-2(3H)-furanone; 4,5-Dihydro-3-(1,3-benzodioxol-5-ylmethyl)-4-[(3,4-dimethoxyphenyl)methyl]-2(3H)-furanone, (3R,4R)-; (3R-cis)-3-(1,3-Benzodioxol-5-ylmethyl)-4-[(3,4-dimethoxyphenyl)methyl]-2-oxetanone (related lactone form); Furan-2(3H)-one derivative; Chiral Dihydrofuranone Intermediate
EINECS	Contact for details

Quality Control

Every batch of (3R,4R)-3-[(1,3-Benzodioxole-5-Yl)Methyl]-4-(3,4-Dimethoxybenzyl)-4,5-Dihydrofuran-2(3H)-One is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and stereochemical integrity. Our quality assurance protocol is designed to meet the stringent requirements of research and cGMP (where applicable) environments. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), chiral purity, and related substances is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (3R,4R)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.