Description

Hydroxocobalamin Hydrochloride is a highly purified, crystalline form of vitamin B12, a vital cofactor in numerous enzymatic processes. Its primary commercial value lies in its use as a direct and stable pharmaceutical active ingredient, offering superior stability compared to other cobalamin forms. This compound is essential for manufacturers in the pharmaceutical, nutraceutical, and advanced research sectors requiring a reliable source for injectable formulations, dietary supplements, and biochemical research.

Application

• Pharmaceutical Active Ingredient: Primary use in the manufacture of injectable vitamin B12 solutions for the treatment of pernicious anemia and other B12 deficiencies.
• Nutraceutical Formulations: Key component in high-potency dietary supplements, tablets, and capsules aimed at supporting energy metabolism and neurological health.
• Diagnostic Reagent: Used in clinical diagnostic kits and assays for the measurement of vitamin B12 levels in serum.
• Biochemical Research: Serves as a critical reagent in enzymology, cell culture media supplementation, and metabolic pathway studies.
• Veterinary Medicine: Incorporated into animal health products for the treatment of B12 deficiencies in livestock and companion animals.
• Food Fortification: Employed for the nutritional fortification of specific food products, though less common than cyanocobalamin due to cost and stability factors.

Basic Information

Product Name	Hydroxocobalamin Hydrochloride
CAS No.	58288-50-9
Molecular Formula	C62H90ClCoN13O15P
Molecular Weight	1382.73 g/mol
Synonyms	Vitamin B12a Hydrochloride; Hydroxocobalamin HCl; Aquocobalamin Hydrochloride; α-(5,6-Dimethylbenzimidazolyl)hydroxocobamide Hydrochloride; Hydroxocobalamin Chloride; Cobalamin Hydroxide Monohydrochloride; B12 Vitamin Hydrochloride; Hydroxocobalamin (Hydrochloride)
EINECS	261-280-5

Quality Control

Our Hydroxocobalamin Hydrochloride is manufactured under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and potency, aligning with pharmaceutical-grade expectations. Certificates of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological limits are provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	Dark red crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference
Assay (on dried basis)	96.0% - 102.0%
pH (1% solution)	4.0 - 6.0
Loss on Drying	≤ 12.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Microbiological Enumeration	Total aerobic microbial count ≤ 1000 cfu/g Total combined yeasts/molds ≤ 100 cfu/g
Specific Pathogens	Absent (E. coli, Salmonella)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.