Description

Methyl (2S,4R)-4-Fluoroprolinate is a high-purity, chiral fluorinated proline derivative. This compound is a critical building block in modern pharmaceutical synthesis, valued for its ability to introduce conformational rigidity and metabolic stability into drug molecules. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other biologically active molecules.
• Peptidomimetics: Used to incorporate fluorinated proline motifs into peptide backbones to enhance stability, bioavailability, and binding affinity.
• Agrochemical Research: Serves as a building block for developing new herbicides and pesticides with improved efficacy and environmental profiles.
• Chemical Biology Probes: Utilized in the design of fluorinated probes for studying enzyme mechanisms and protein-ligand interactions.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective catalytic reactions.
• Material Science: Potential precursor for specialty polymers and advanced materials with unique properties.

Basic Information

Product Name	Methyl (2S,4R)-4-Fluoroprolinate
CAS No.	58281-80-4
Molecular Formula	C₆H₁₀FNO₂
Molecular Weight	147.15 g/mol
Synonyms	Methyl (2S,4R)-4-fluoropyrrolidine-2-carboxylate; (2S,4R)-4-Fluoroproline methyl ester; L-4-Fluoroproline methyl ester (trans); (4R)-Fluoro-L-proline methyl ester; Methyl trans-4-fluoro-L-prolinate; 4-Fluoro-L-proline methyl ester; 58281-80-4; Methyl (2S,4R)-4-fluoroprolinate
EINECS	Contact for details

Quality Control

Our Methyl (2S,4R)-4-Fluoroprolinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and chiral integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.