Description

(2S,4S)-4-Fluoro-2-Methoxycarbonyl-Pyrrolidine Hcl CAS NO 58281-79-1 is a high-purity, chiral fluorinated pyrrolidine derivative, serving as a critical building block in modern synthetic organic chemistry. Its value lies in its unique stereochemistry and fluorine atom, which are essential for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This advanced pharmaceutical intermediate is primarily needed by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other enzyme-targeted drugs.
• Drug Discovery & Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to introduce fluorine and explore its effects on potency, selectivity, and ADMET profiles.
• Peptidomimetics Development: Incorporated into peptide backbones to enhance metabolic stability and membrane permeability of peptide-based drug candidates.
• Agrochemical Research: Serves as a precursor in the development of advanced, fluorinated agrochemicals with improved efficacy.
• Asymmetric Synthesis: Employed as a chiral auxiliary or scaffold in catalytic asymmetric reactions to construct complex molecular architectures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	(2S,4S)-4-Fluoro-2-Methoxycarbonyl-Pyrrolidine Hydrochloride
CAS No.	58281-79-1
Molecular Formula	C7H13FNO2 • HCl
Molecular Weight	209.64 g/mol
Synonyms	(2S,4S)-4-Fluoro-2-(methoxycarbonyl)pyrrolidine hydrochloride; (2S,4S)-Methyl 4-fluoropyrrolidine-2-carboxylate hydrochloride; (2S,4S)-4-Fluoro-L-proline methyl ester hydrochloride; (2S,4S)-4-Fluoro-2-carbomethoxypyrrolidine HCl; L-4-Fluoroproline methyl ester hydrochloride (cis isomer); cis-4-Fluoro-L-proline methyl ester hydrochloride; 4-Fluoro-2-methoxycarbonylpyrrolidine hydrochloride (2S,4S)-form
EINECS	Contact for details

Quality Control

Our (2S,4S)-4-Fluoro-2-Methoxycarbonyl-Pyrrolidine HCl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with high-grade pharmaceutical intermediate standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.