Description

Boc-Ala-Otbu CAS NO 58177-77-8 is a high-purity, protected amino acid derivative, specifically N-(tert-Butoxycarbonyl)-L-alanine tert-butyl ester. This compound serves as a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled elongation of peptide chains. It is essential for research and production in pharmaceutical development, biotechnology, and advanced materials science, where precise molecular assembly is required.

Application

• Peptide Synthesis Intermediate: A key reagent in the stepwise synthesis of complex peptides and proteins, particularly using Fmoc/t-Boc strategies.
• Pharmaceutical Research & Development: Used in the discovery and production of peptide-based active pharmaceutical ingredients (APIs) and therapeutic candidates.
• Bioconjugation: Facilitates the site-specific modification of peptides for drug delivery systems and diagnostic probes.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Biochemical Research: Acts as a substrate or precursor in enzymatic studies and metabolic pathway investigations.
• Material Science: Used in the development of bio-inspired polymers and functionalized surfaces.

Basic Information

Product Name	Boc-Ala-Otbu
CAS No.	58177-77-8
Molecular Formula	C₁₃H₂₅NO₄
Molecular Weight	259.34 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-alanine tert-butyl ester; tert-Butyl N-[(tert-butoxy)carbonyl]-L-alaninate; Boc-L-alanine tert-butyl ester; Boc-Ala-OtBu; (S)-2-((tert-Butoxycarbonyl)amino)propanoic acid tert-butyl ester; BOC-ALA-OTBU; BOC-L-ALA-OTBU; N-Boc-L-alanine tert-butyl ester
EINECS	Contact for details

Quality Control

Our Boc-Ala-Otbu is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and cGMP-grade standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]²⁰D	-20° to -25° (c=1 in methanol)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Melting Point	78°C - 82°C
Loss on Drying	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.