Description

(R)-Chloroquine is the enantiomerically pure form of the well-known antimalarial compound, distinguished by its specific three-dimensional molecular configuration. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the study of stereospecific biological activity and the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of advanced fine chemicals for applications in enantioselective synthesis and pharmacological studies.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the research and synthesis of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Stereochemical Research: Used as a reference standard in studies investigating the differential biological effects, metabolism, and pharmacokinetics of chloroquine enantiomers.
• Antimalarial Drug Development: Employed in the development and testing of next-generation antimalarial therapies with potentially improved efficacy or reduced side-effect profiles.
• Biochemical Tool Compound: Applied in in vitro assays to explore specific receptor interactions and cellular pathways influenced by the (R)-enantiomer.
• Process Chemistry: Utilized in the development and optimization of asymmetric synthesis routes within fine chemical production.

Basic Information

Product Name	(R)-Chloroquine
CAS No.	58175-87-4
Molecular Formula	C₁₈H₂₆ClN₃
Molecular Weight	319.87 g/mol
Synonyms	(R)-N'-(7-Chloro-4-quinolinyl)-N,N-diethyl-1,4-pentanediamine; (R)-Chloroquine base; (+)-Chloroquine; (R)-Chloroquine diphosphate (salt form); Dextro-chloroquine; (R)-CQ; AR-C 155858 (historical context); UNII-3Q1X6L8Q3R
EINECS	Contact for details

Quality Control

Our (R)-Chloroquine is produced under strict quality management systems to ensure high enantiomeric purity and chemical integrity, suitable for research applications. Each batch is characterized using advanced analytical techniques including chiral HPLC to confirm identity and purity. Certificates of Analysis (COA) detailing specific test results are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.