Description

Dmaba Nhs Ester CAS NO 58068-85-2 is a high-purity, activated ester derivative primarily used as a key intermediate in bioconjugation and peptide synthesis. This compound is critical for creating stable amide bonds, enabling the precise labeling and modification of biomolecules like proteins and antibodies. It is an essential reagent for researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors who require reliable and efficient cross-linking agents.

Application

• Bioconjugation Reagent: For the covalent attachment of dyes, probes, drugs, or other molecules to proteins, peptides, and antibodies.
• Peptide Synthesis Intermediate: Used in solid-phase and solution-phase peptide synthesis to incorporate specific functional groups.
• Diagnostic Kit Manufacturing: A key component in the production of enzyme-linked immunosorbent assay (ELISA) kits and other immunoassays.
• ADC (Antibody-Drug Conjugate) Development: Facilitates the linker chemistry required to attach cytotoxic payloads to monoclonal antibodies.
• Biomaterial Functionalization: Used to modify surfaces of polymers, nanoparticles, or gels with bioactive ligands.
• Fluorescent Labeling: Enables the preparation of fluorescently tagged biomolecules for imaging and flow cytometry.

Basic Information

Product Name	Dmaba Nhs Ester
CAS No.	58068-85-2
Molecular Formula	C13H12N2O5
Molecular Weight	276.25 g/mol
Synonyms	4-[(Dimethylamino)benzylamino]-4-oxobutanoic Acid N-Hydroxysuccinimide Ester; DMABA NHS Ester; DMABA-OSu; N-Succinimidyl 4-[(4-Dimethylaminobenzyl)amino]-4-oxobutanoate; 4-(Dimethylaminobenzylamino)succinic Acid N-Hydroxysuccinimide Ester; N-(4-Dimethylaminobenzyl)succinamic Acid N-Hydroxysuccinimide Ester; DMABA Active Ester
EINECS	Contact for details

Quality Control

Our Dmaba Nhs Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.