Description

n-(Trifluoroacetyl)-L-Glutamic Acid Bis(1-Methylpropyl) Ester is a high-purity, protected amino acid derivative designed for advanced synthetic applications. This compound is a critical building block in the synthesis of complex peptides and other bioactive molecules, offering enhanced reactivity and stability for demanding chemical processes. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, process development, and the production of fine chemicals.

Application

• Pharmaceutical Intermediate: A key protected intermediate in the multi-step synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce glutamic acid residues with orthogonal protecting groups.
• Bioconjugation & Labeling: Serves as a precursor for creating modified amino acids used in bioconjugation strategies for drug delivery systems or diagnostic probes.
• Chemical Research: Employed in academic and industrial R&D for exploring new synthetic methodologies and constructing novel molecular architectures.
• Prodrug Development: Utilized in the design and synthesis of prodrugs, where the ester groups can be tailored for specific enzymatic cleavage and release profiles.
• Agrochemical Synthesis: Acts as a specialty intermediate in the development of advanced, high-performance agrochemicals.

Basic Information

Product Name	n-(Trifluoroacetyl)-L-Glutamic Acid Bis(1-Methylpropyl) Ester
CAS No.	57983-23-0
Molecular Formula	C15H24F3NO5
Molecular Weight	355.35 g/mol
Synonyms	L-Glutamic acid, N-(trifluoroacetyl)-, bis(1-methylpropyl) ester; N-Trifluoroacetyl-L-glutamic acid di-sec-butyl ester; (2S)-2-[(Trifluoroacetyl)amino]pentanedioic acid bis(sec-butyl) ester; N-TFA-L-glutamic acid α,γ-di-sec-butyl ester; Bis(sec-butyl) N-(trifluoroacetyl)-L-glutamate; N-(Trifluoroacetyl)glutamic acid di-sec-butyl ester
EINECS	Contact for details

Quality Control

Our n-(Trifluoroacetyl)-L-Glutamic Acid Bis(1-Methylpropyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR, and MS for structural confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.