Description

N,o-Di(Trifluoroacetyl)-L-Serine 1-Methylpropyl Ester is a specialized, high-purity chiral building block and protected amino acid derivative. This compound is critical for advanced organic synthesis, particularly in the development of pharmaceuticals and bioactive peptides, where it serves as a key intermediate. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemistry and functional group protection for complex molecule assembly.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), especially for protease inhibitors and other peptide-based therapeutics.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected serine derivative, enabling the controlled elongation of peptide chains.
• Agrochemical Research: Serves as a building block for developing chiral pesticides and herbicides with enhanced efficacy and selectivity.
• Bioconjugation & Probe Development: Utilized in the creation of fluorescent probes, affinity labels, and other bioconjugates for biochemical and diagnostic applications.
• Material Science: Potential monomer or modifier in the synthesis of specialized polymers with unique surface properties or biodegradability.
• Academic & Process R&D: A valuable reagent for methodological development in asymmetric synthesis and for scaling up synthetic routes in process chemistry.

Basic Information

Product Name	N,o-Di(Trifluoroacetyl)-L-Serine 1-Methylpropyl Ester
CAS No.	57983-19-4
Molecular Formula	C11H14F6NO5
Molecular Weight	354.23 g/mol
Synonyms	L-Serine, N,o-bis(trifluoroacetyl)-, 1-methylpropyl ester; (2S)-2-[Bis(trifluoroacetyl)amino]-3-hydroxypropanoic acid sec-butyl ester; N,O-Bis(trifluoroacetyl)-L-serine sec-butyl ester; sec-Butyl N,O-bis(trifluoroacetyl)-L-serinate; BTF-Ser-O-sec-Bu; Protected L-Serine sec-butyl ester
EINECS	Contact for details

Quality Control

Every batch of N,o-Di(Trifluoroacetyl)-L-Serine 1-Methylpropyl Ester is produced and tested under a strict quality management system. We ensure high chemical and chiral purity through advanced analytical techniques including HPLC, NMR, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee consistency and support your regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.