Description

n-(Trifluoroacetyl)-L-Glutamic Acid Bis(1-Methylbutyl) Ester is a high-purity, specialty fluorinated amino acid derivative designed for advanced chemical synthesis. This compound is valued for its role as a key chiral building block and protecting group intermediate in complex organic transformations. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and development of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated pesticide and herbicide molecules, leveraging the trifluoroacetyl group's metabolic stability.
• Peptide Chemistry: Acts as a protected glutamic acid derivative for solid-phase peptide synthesis (SPPS) and solution-phase peptide coupling reactions.
• Protecting Group Strategy: The trifluoroacetyl (TFA) group provides a base-labile protecting group for amines, useful in multi-step synthetic sequences.
• Bioconjugation & Probe Development: Employed in the synthesis of fluorescent probes, imaging agents, and bioconjugates for biochemical and diagnostic research.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced functional materials with unique surface properties.

Basic Information

Product Name	n-(Trifluoroacetyl)-L-Glutamic Acid Bis(1-Methylbutyl) Ester
CAS No.	57983-12-7
Molecular Formula	C₁₇H₂₈F₃NO₅
Molecular Weight	383.41 g/mol
Synonyms	L-Glutamic acid, N-(trifluoroacetyl)-, bis(1-methylbutyl) ester; N-Trifluoroacetyl-L-glutamic acid bis(1-methylbutyl) ester; N-TFA-L-glutamic acid bis(sec-pentyl) ester; (S)-2-(Trifluoroacetamido)pentanedioic acid bis(1-methylbutyl) ester; Glutamic acid, N-trifluoroacetyl-, bis(1-methylbutyl) ester, L-; Bis(1-methylbutyl) N-(trifluoroacetyl)-L-glutamate
EINECS	Contact for details

Quality Control

Our production of n-(Trifluoroacetyl)-L-Glutamic Acid Bis(1-Methylbutyl) Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure consistency and compliance with research-grade specifications. A detailed Certificate of Analysis (COA) providing HPLC/GC assay, optical rotation, and identity confirmation is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to preserve optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.