Description

2-[(Trifluoromethyl)Sulfonyl]-Pyridine is a high-value organosulfur and organofluorine building block characterized by its reactive sulfonyl and electron-withdrawing trifluoromethyl groups. This compound matters for its critical role in facilitating complex molecular transformations, particularly in the synthesis of advanced agrochemicals and pharmaceuticals. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries seeking to introduce the potent trifluoromethanesulfonyl moiety into heterocyclic systems.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethylsulfonyl group enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic electronic materials.
• Cross-Coupling Reactions: Acts as an electrophilic coupling partner in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Fluorine Chemistry Research: A valuable reagent for studying the introduction and effects of fluorine-containing functional groups in organic molecules.

Basic Information

Product Name	2-[(Trifluoromethyl)Sulfonyl]-Pyridine
CAS No.	57830-55-4
Molecular Formula	C6H4F3NO2S
Molecular Weight	211.16 g/mol
Synonyms	Pyridine, 2-[(trifluoromethyl)sulfonyl]-; 2-(Trifluoromethylsulfonyl)pyridine; 2-Pyridyl Trifluoromethyl Sulfone; α,α,α-Trifluoro-2-pyridylmethyl sulfone; 2-Trifluoromethanesulfonylpyridine; 2-Tf-Pyridine; 2-Pyridyl Tf
EINECS	Contact for details

Quality Control

Our 2-[(Trifluoromethyl)Sulfonyl]-Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.