Description

Cyclobutanecarboxylic Acid, 2-Methyl-, Methyl Ester, (1R,2R)-Rel- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its rigid cyclobutane core and defined stereochemistry make it a valuable precursor for constructing complex molecular architectures with precise three-dimensional control. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its unique structural features can impart desirable biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders or requiring specific steric profiles.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the cyclobutane ring can enhance photostability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to induce high enantioselectivity in critical bond-forming reactions.
• Material Science Research: Investigated as a monomer or building block for specialty polymers with unique thermal and mechanical properties derived from the strained cyclobutane structure.
• Flavor and Fragrance Chemistry: Potential intermediate for synthesizing complex, musky, or amber-type odorants where the methylated cyclobutane framework contributes to the scent profile.
• Academic and Process Chemistry: Employed in methodological studies and scale-up process development for stereoselective synthesis routes.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 2-Methyl-, Methyl Ester, (1R,2R)-Rel- (9Ci)
CAS No.	57705-62-1
Molecular Formula	C7H12O2
Molecular Weight	128.17 g/mol
Synonyms	(1R,2R)-rel-2-Methylcyclobutanecarboxylic Acid Methyl Ester; Methyl (1R,2R)-rel-2-Methylcyclobutanecarboxylate; rel-(1R,2R)-Methyl 2-Methylcyclobutanecarboxylate; 2-Methylcyclobutanecarboxylic Acid Methyl Ester, (1R,2R)-rel-; Methyl 2-Methylcyclobutanecarboxylate (rel-(1R,2R)-form)
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including chiral HPLC, GC, NMR, and IR spectroscopy. Certificates of Analysis (COA) detailing identity, purity, and stereochemical composition are provided with every shipment. We support development from milligram to kilogram scale under quality systems designed for cGMP compliance for pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong alkali and incompatible materials such as strong oxidizing agents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Purity (GC)	≥ 97.0% (Area %)
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% (rel-(1R,2R))
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.