Description

5-Hydroxyprimaquine is a key metabolite and synthetic intermediate of the antimalarial drug primaquine. This compound matters for researchers and manufacturers focused on developing and analyzing antimalarial therapies, as it plays a crucial role in understanding drug metabolism and efficacy. It is primarily needed by the pharmaceutical, biotechnology, and academic research sectors for use in drug discovery, metabolite studies, and analytical reference standards.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control and analytical method development in drug manufacturing.
• Metabolite Research: Critical for in vitro and in vivo studies investigating the metabolic pathway, pharmacokinetics, and bioactivation of primaquine.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a high-purity building block in the synthetic route for antimalarial drugs and related analogs.
• Biochemical Assay Development: Employed in the development of diagnostic kits and enzymatic assays to study drug action and resistance mechanisms.
• Academic & Contract Research: Utilized in university and CRO laboratories for fundamental research on parasitic diseases and medicinal chemistry.

Basic Information

Product Name	5-Hydroxyprimaquine
CAS No.	57695-07-5
Molecular Formula	C₁₅H₂₁N₃O₂
Molecular Weight	275.35 g/mol
Synonyms	5-Hydroxyprimaquine; 8-[(4-Amino-1-methylbutyl)amino]-6-methoxyquinolin-5-ol; Primaquine, 5-hydroxy-; 5-HPQ; NSC 351939; WR 297855; 6-Methoxy-8-[(4-amino-1-methylbutyl)amino]quinolin-5-ol
EINECS	Contact for details

Quality Control

Our 5-Hydroxyprimaquine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR), to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.