Description

Isopropyl Melphalan is a chemically modified derivative of the alkylating agent melphalan, designed to alter its pharmacokinetic profile and therapeutic potential. This compound is of significant interest in pharmaceutical research and development, particularly for its potential application in targeted cancer therapies. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in oncology drug discovery and advanced intermediate synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel, potentially more selective chemotherapeutic agents.
• Oncology Research: Used in preclinical studies to investigate structure-activity relationships (SAR) and the efficacy of melphalan analogs.
• Prodrug Development: Explored as a prodrug candidate, where the isopropyl group may influence solubility, stability, or targeted delivery.
• Biochemical Research: Employed in studies examining DNA alkylation mechanisms and cellular resistance pathways.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Item	Detail
Product Name	Isopropyl Melphalan
CAS No.	57675-29-3
Molecular Formula	C16H23Cl2N3O4
Molecular Weight	392.28 g/mol
Synonyms	L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-N-(1-methylethoxy)carbonyl-; 4-[Bis(2-chloroethyl)amino]-L-phenylalanine N-(1-methylethyl) ester; Isopropyl ester of Melphalan; L-Melphalan isopropyl ester; NSC 394854
EINECS	Contact for details

Quality Control

Our Isopropyl Melphalan is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for research and development purposes. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical manufacturing, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.