Description

(17S)-17-Methyl-3β-(Trimethylsiloxy)Androst-5-En-17β-Ol CAS NO 57397-40-7 is a high-purity, steroidal intermediate featuring a trimethylsilyl (TMS) protecting group on the 3β-hydroxyl position. This compound is critical for synthetic organic chemistry, particularly in the pharmaceutical sector, where it serves as a key building block for the development of novel steroid-based therapeutics and research compounds. It is primarily utilized by R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and fine chemical industries for advanced synthesis and process optimization.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of advanced steroid-based active pharmaceutical ingredients (APIs) and drug candidates.
• Research & Development: Used in academic and industrial R&D for exploring new synthetic pathways, structure-activity relationships (SAR), and novel steroid derivatives.
• Process Chemistry: Employed in process development and scale-up for optimizing yield and purity in the manufacturing of complex steroid molecules.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in HPLC and GC analysis within QC laboratories.
• Fine Chemical Synthesis: Acts as a specialized building block for synthesizing custom steroidal compounds for various biochemical and material science applications.

Basic Information

Item	Detail
Product Name	(17S)-17-Methyl-3β-(Trimethylsiloxy)Androst-5-En-17β-Ol
CAS No.	57397-40-7
Molecular Formula	C23H40O2Si
Molecular Weight	376.65 g/mol
Synonyms	17α-Methyl-3β-(trimethylsiloxy)androst-5-en-17β-ol; (17S)-17-Methyl-3-(trimethylsilyloxy)androst-5-en-17-ol; 3β-Trimethylsiloxy-17α-methyl-androst-5-en-17β-ol; 17-Methyl-3-trimethylsiloxyandrost-5-en-17-ol; Androst-5-en-17-ol, 17-methyl-3-[(trimethylsilyl)oxy]-, (3β,17β)-; 57397-40-7; TMS Ether of 17α-Methylandrost-5-ene-3β,17β-diol
EINECS	Contact for details

Quality Control

Our (17S)-17-Methyl-3β-(Trimethylsiloxy)Androst-5-En-17β-Ol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.