Description

2-[(Trimethylsilyl)Amino]-3-(Trimethylsiloxy)Benzoic Acid Methyl Ester is a specialized organosilicon-protected intermediate of significant value in advanced organic synthesis. Its core value proposition lies in enabling complex, multi-step synthetic routes by providing orthogonal protection for amine and hydroxyl groups under mild conditions. This compound is essential for research chemists and process development scientists in the pharmaceutical and fine chemical industries, particularly for the synthesis of complex molecules, active pharmaceutical ingredients (APIs), and novel heterocyclic compounds.

Application

• Key intermediate in the multi-step synthesis of complex pharmaceutical Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Building block for the preparation of novel heterocyclic compounds and functionalized benzoic acid derivatives.
• Protected synthon in peptide mimetics and medicinal chemistry research, where selective deprotection is required.
• Precursor in material science for the synthesis of functionalized siloxanes and specialty polymers.
• Reagent in methodology development for new silylation and desilylation reactions.
• Intermediate for producing agrochemicals and other high-value specialty chemicals.

Basic Information

Product Name	2-[(Trimethylsilyl)Amino]-3-(Trimethylsiloxy)Benzoic Acid Methyl Ester
CAS No.	57397-09-8
Molecular Formula	C14H23NO3Si2
Molecular Weight	309.51 g/mol
Synonyms	Methyl 2-[(Trimethylsilyl)Amino]-3-(Trimethylsiloxy)Benzoate; 2-(Trimethylsilylamino)-3-(trimethylsiloxy)benzoic Acid Methyl Ester; Benzoic acid, 2-[(trimethylsilyl)amino]-3-(trimethylsiloxy)-, methyl ester; Methyl 2-(N-trimethylsilylamino)-3-(trimethylsiloxy)benzoate; 2-Amino-3-hydroxybenzoic acid methyl ester bis(trimethylsilyl) derivative; TMS-protected methyl anthranilate derivative
EINECS	Contact for details

Quality Control

Our 2-[(Trimethylsilyl)Amino]-3-(Trimethylsiloxy)Benzoic Acid Methyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP principles and adherence to relevant ICH guidelines ensure a reliable supply for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccated environment to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.