Description

Pregnan-11-One, 3,20,21-Tris[(Trimethylsilyl)Oxy]-, (3Alpha,5Beta,20S) is a high-purity, multi-functional steroid derivative characterized by its three trimethylsilyl (TMS) protecting groups. This compound is a critical advanced intermediate in the synthesis of complex steroid-based pharmaceuticals, offering precise control over stereochemistry and functional group manipulation. It is primarily utilized by research institutions and pharmaceutical manufacturers specializing in the development of corticosteroids, anti-inflammatory agents, and other therapeutic steroids.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent corticosteroid drugs, such as those targeting inflammation and autoimmune disorders.
• Organic Synthesis Research: Used in academic and industrial R&D for studying steroid functionalization, protecting group strategies, and reaction mechanisms.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in steroid analysis.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for steroid APIs (Active Pharmaceutical Ingredients) under GMP conditions.
• Biochemical Research: Used as a precursor or probe in studies investigating steroid hormone receptors and metabolic pathways.

Basic Information

Product Name	Pregnan-11-One, 3,20,21-Tris[(Trimethylsilyl)Oxy]-, (3Alpha,5Beta,20S)
CAS No.	57377-54-5
Molecular Formula	C30H58O4Si3
Molecular Weight	567.04 g/mol
Synonyms	(3α,5β,20S)-3,20,21-Tris[(trimethylsilyl)oxy]pregnan-11-one; 11-Oxopregnane-3,20,21-triol 3,20,21-tris(trimethylsilyl) ether; 3,20,21-Tris-O-(trimethylsilyl)-11-oxopregnane; 11-Ketopregnane-3,20,21-triol TMS ether; TMS-protected 11-oxopregnane triol; Steroid TMS ether intermediate; Pregnane-11-one TMS derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for advanced pharmaceutical intermediates. Each batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing all relevant specifications are available upon request. We support development under quality systems aligned with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants or storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.