Description

3α,17,21-Tris(Trimethylsiloxy)-20-(Phenylmethoxyimino)-5β-Pregnan-11-One is a high-purity, advanced steroid derivative and a key synthetic intermediate in pharmaceutical research and development. Its value lies in its functionalized structure, which is critical for the synthesis of complex bioactive molecules, particularly corticosteroids and other therapeutic agents. This compound is essential for R&D chemists and process development scientists in the pharmaceutical and fine chemical industries seeking reliable, high-quality building blocks for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of potent corticosteroid drugs and other steroidal pharmaceuticals.
• Research & Development: Used in medicinal chemistry for the discovery and structural modification of new therapeutic agents targeting inflammation and immune response.
• Process Chemistry: Serves as a key intermediate in the scale-up and optimization of manufacturing processes for active pharmaceutical ingredients (APIs).
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Employed in studies investigating steroid hormone pathways, receptor binding, and metabolic transformations.

Basic Information

Product Name	3α,17,21-Tris(Trimethylsiloxy)-20-(Phenylmethoxyimino)-5β-Pregnan-11-One
CAS No.	57325-96-9
Molecular Formula	C36H61NO5Si3
Molecular Weight	684.13 g/mol
Synonyms	3α,17,21-Tris(trimethylsilyloxy)-20-(phenylmethoxyimino)-5β-pregnan-11-one; 20-(Benzyloxyimino)-3α,17,21-tris(trimethylsiloxy)-5β-pregnan-11-one; 5β-Pregnan-11-one, 3α,17,21-tris(trimethylsiloxy)-20-[(phenylmethoxy)imino]-; Steroid TMS Derivative; 11-Keto Steroid Intermediate; Pregnane TMS Ether Oxime
EINECS	Contact for details

Quality Control

Every batch of 3α,17,21-Tris(Trimethylsiloxy)-20-(Phenylmethoxyimino)-5β-Pregnan-11-One is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency that meet the exacting standards of pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.