Description

Pregn-4-En-3-One, 11,17,20,21-Tetrakis[(Trimethylsilyl)Oxy]-, o-Methyl Oxime, (11Beta,20R)- is a high-purity, multi-protected steroid derivative, specifically designed for advanced pharmaceutical research and synthesis. This compound serves as a critical synthetic intermediate, offering precise stereochemical control for the development of novel corticosteroid analogs and other bioactive molecules. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors engaged in steroid chemistry, process development, and the synthesis of complex therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex corticosteroid drugs and their analogs.
• Process Chemistry: Used in research and development for optimizing synthetic routes to steroidal active pharmaceutical ingredients (APIs).
• Biochemical Research: Serves as a precursor or reference standard in studies investigating steroid hormone metabolism and receptor interactions.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the production of specialized, high-value steroidal compounds.
• Academic Research: Utilized in university and institutional laboratories for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	Pregn-4-En-3-One, 11,17,20,21-Tetrakis[(Trimethylsilyl)Oxy]-, o-Methyl Oxime, (11Beta,20R)-
CAS No.	57325-92-5
Molecular Formula	C33H65NO5Si4
Molecular Weight	668.2 g/mol
Synonyms	(11β,20R)-11,17,20,21-Tetrakis[(trimethylsilyl)oxy]pregn-4-en-3-one o-methyl oxime; 11β,17α,20,21-Tetrahydroxypregn-4-en-3-one 20-methyl oxime 11,17,20,21-tetrakis-O-(trimethylsilyl) ether; 20-Methyloxime-11β,17α,20,21-tetrahydroxypregn-4-en-3-one tetrakis(trimethylsilyl) ether; Tetrakis-O-TMS derivative of 20-methyloxime hydrocortisone; Steroid TMS derivative; Hydrocortisone 20-methyloxime tetrakis(trimethylsilyl) ether
EINECS	Contact for details

Quality Control

Our Pregn-4-En-3-One, 11,17,20,21-Tetrakis[(Trimethylsilyl)Oxy]-, o-Methyl Oxime, (11Beta,20R)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and mass spectrometry to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee consistency and reliability for your critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.