Description

3α,21-Bis(Trimethylsiloxy)-5β-Pregnan-20-One o-Benzyl Oxime is a high-purity, synthetic steroid derivative characterized by its specific siloxy-protected functional groups. This compound serves as a critical advanced intermediate in the synthesis of complex pharmaceutical actives, offering precise control over molecular structure for downstream reactions. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of specialized steroid-based therapeutics and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex steroid-based active pharmaceutical ingredients (APIs).
• Steroid Research & Development: Used in academic and industrial R&D for exploring novel steroid derivatives and their biological activities.
• Process Chemistry: Employed in route scouting and optimization for the commercial-scale production of target steroid molecules.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Fine Chemical Synthesis: Utilized in the preparation of other specialized, high-value chemical entities requiring a protected pregnane backbone.

Basic Information

Product Name	3α,21-Bis(Trimethylsiloxy)-5β-Pregnan-20-One o-Benzyl Oxime
CAS No.	57325-89-0
Molecular Formula	C33H55NO3Si2
Molecular Weight	570.0 g/mol (approx.)
Synonyms	5β-Pregnan-20-one, 3α,21-bis[(trimethylsilyl)oxy]-, O-(phenylmethyl)oxime; 3α,21-Bis-O-(trimethylsilyl)-5β-pregnan-20-one O-benzyloxime; 3α,21-Bis(trimethylsiloxy)-5β-pregnan-20-one O-benzyl oxime; Pregnane-3α,21-diol, 20-one O-benzyloxime bis(trimethylsilyl) ether; 57325-89-0; Steroid silyl ether intermediate; Pregnane oxime derivative
EINECS	Contact for details

Quality Control

Our 3α,21-Bis(Trimethylsiloxy)-5β-Pregnan-20-One o-Benzyl Oxime is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical intermediate use. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.