Description

(20S)-3β,11,17,20-Tetrakis(Trimethylsiloxy)Pregna-5,11-Diene is a high-purity, advanced steroid intermediate featuring a unique diene structure and multiple trimethylsilyl (TMS) protecting groups. This compound is critical for enabling complex synthetic pathways in pharmaceutical research and development, offering precise control over stereochemistry and reactivity. It is primarily utilized by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for the synthesis of novel steroid-based therapeutics and reference standards.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex steroid-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the exploration and development of new drug candidates targeting hormone receptors.
• Process Chemistry: Serves as a critical intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Custom Synthesis: A starting material for the custom synthesis of specialized steroid derivatives for research applications.

Basic Information

Product Name	(20S)-3β,11,17,20-Tetrakis(Trimethylsiloxy)Pregna-5,11-Diene
CAS No.	57325-82-3
Molecular Formula	C34H66O4Si4
Molecular Weight	651.2 g/mol
Synonyms	3β,11β,17α,20-Tetrakis(trimethylsiloxy)pregna-5,11-diene; (20S)-Pregna-5,11-diene-3β,11β,17α,20-tetrol, 3β,11β,17α,20-tetrakis(trimethylsilyl) ether; 3β,11β,17α,20-Tetrakis-O-(trimethylsilyl)pregna-5,11-diene; 5,11-Diene TMS Ether Intermediate; Steroid TMS Ether Derivative; Pregna-5,11-diene TMS Protected Intermediate
EINECS	Contact for details

Quality Control

Our (20S)-3β,11,17,20-Tetrakis(Trimethylsiloxy)Pregna-5,11-Diene is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing including HPLC, GC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.