Description

[[(20R)-5α-Pregnane-3β,17,20-Triyl]Tri(Oxy)]Tris(Trimethylsilane) CAS NO 57305-42-7 is a high-purity, trimethylsilyl-protected derivative of a key pregnane steroid intermediate. This compound is of significant value in synthetic organic and medicinal chemistry, primarily serving as a crucial protected synthon for the controlled functionalization of the steroid core. It is essential for researchers and manufacturers in the pharmaceutical industry, particularly those developing novel steroid-based therapeutics, hormone analogs, and advanced chemical probes.

Application

• Pharmaceutical Intermediate: A critical protected building block for the synthesis of complex steroid-based active pharmaceutical ingredients (APIs) and hormone analogs.
• Medicinal Chemistry Research: Used in the discovery and development of new drug candidates targeting nuclear hormone receptors and other steroidal pathways.
• Chemical Synthesis: Serves as a versatile precursor for the selective deprotection and further derivatization at the 3β, 17, and 20 positions of the pregnane skeleton.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling of related steroid compounds.
• Biochemical Tool Compound: Utilized in academic and industrial research to study steroid metabolism, biosynthesis, and enzyme inhibition.

Basic Information

Product Name	[[(20R)-5α-Pregnane-3β,17,20-Triyl]Tri(Oxy)]Tris(Trimethylsilane)
CAS No.	57305-42-7
Molecular Formula	C32H64O3Si3
Molecular Weight	581.10 g/mol
Synonyms	(20R)-5α-Pregnane-3β,17,20-triyl Tris(trimethylsilyl) Ether; 5α-Pregnane-3β,17β,20α-triol Tris(trimethylsilyl) Ether; 3β,17,20-Tris(trimethylsiloxy)-5α-pregnane; Pregnane-3β,17,20-triol Tris(TMS) Ether; Tris-O-trimethylsilyl Pregnane Triol; TMS-protected Pregnane Triol; Steroid TMS Ether Intermediate
EINECS	Contact for details

Quality Control

Our [[(20R)-5α-Pregnane-3β,17,20-Triyl]Tri(Oxy)]Tris(Trimethylsilane) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.