Description

(20R)-20,21-Bis(Trimethylsiloxy)Pregn-4-En-3-One o-Methyl Oxime is a high-purity, advanced steroid intermediate featuring protective siloxy groups and an oxime functionalization. This compound is critical for the synthesis of complex steroid derivatives, offering researchers and manufacturers a reliable building block for developing novel pharmaceutical actives. It is primarily utilized by R&D laboratories and production facilities in the pharmaceutical and fine chemical sectors for the development of steroidal drugs and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel steroidal drugs, including potential anti-inflammatory, hormonal, and neuroactive agents.
• Fine Chemical Synthesis: Serves as a versatile building block in multi-step organic synthesis for creating complex, high-value steroid analogs and derivatives.
• Biochemical Research: Used in academic and industrial research to study steroid receptor interactions, metabolic pathways, and structure-activity relationships (SAR).
• Process Chemistry: Employed in the development and scale-up of synthetic routes for active pharmaceutical ingredients (APIs) within GMP environments.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control, method development, and regulatory submissions.

Basic Information

Product Name	(20R)-20,21-Bis(Trimethylsiloxy)Pregn-4-En-3-One o-Methyl Oxime
CAS No.	57305-30-3
Molecular Formula	C₂₉H₅₃NO₃Si₂
Molecular Weight	520.0 g/mol
Synonyms	20,21-Bis(trimethylsiloxy)pregn-4-en-3-one O-methyloxime; (20R)-20,21-Bis[(trimethylsilyl)oxy]pregn-4-en-3-one O-methyloxime; Pregn-4-ene-3,20-dione, 21-(trimethylsilyl)oxy)-, 3-(O-methyloxime), 20-(trimethylsilyl) ether; 20,21-Bis-O-(trimethylsilyl)-3-(O-methyloximo)pregn-4-ene; Steroid silyl ether oxime intermediate
EINECS	Contact for details

Quality Control

Our (20R)-20,21-Bis(Trimethylsiloxy)Pregn-4-En-3-One o-Methyl Oxime is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Specific Rotation	Contact for details
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.