Description

3,16α,17α-Tris(Trimethylsiloxy)Estra-1,3,5(10)-Triene is a high-purity, organosilicon-protected derivative of estra-1,3,5(10)-triene, a key steroid nucleus. This compound is specifically engineered to provide enhanced stability and solubility for advanced synthetic applications, serving as a crucial protected intermediate. It is primarily utilized by research institutions and pharmaceutical development laboratories engaged in the synthesis of novel steroid-based therapeutics, hormone analogs, and other high-value fine chemicals. The product's design facilitates precise chemical modifications while safeguarding reactive hydroxyl groups.

Application

• Pharmaceutical Intermediate: A critical protected synthon for the research and development of novel steroidal drugs and hormone receptor modulators.
• Organic Synthesis Building Block: Used in multi-step synthetic routes to create complex steroid frameworks for academic and industrial research.
• Biochemical Research: Employed in studies investigating steroid metabolism, receptor binding, and the structure-activity relationships (SAR) of estrogenic compounds.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Material Science Precursor: Potential use in the development of specialized polymers or coatings with unique properties derived from the steroid backbone.

Basic Information

Product Name	3,16α,17α-Tris(Trimethylsiloxy)Estra-1,3,5(10)-Triene
CAS No.	57305-23-4
Molecular Formula	C27H48O3Si3
Molecular Weight	505.0 g/mol (approx.)
Synonyms	Estra-1,3,5(10)-triene-3,16α,17α-triol, tris(trimethylsilyl) ether; 3,16α,17α-Tris-O-(trimethylsilyl)estra-1,3,5(10)-triene; Tris(trimethylsiloxy)estra-1,3,5(10)-triene; Estra-1,3,5(10)-triene-3,16,17-triol TMS ether; TMS-protected estra-1,3,5(10)-triene triol; 57305-23-4; Steroid TMS ether derivative
EINECS	Contact for details

Quality Control

Our 3,16α,17α-Tris(Trimethylsiloxy)Estra-1,3,5(10)-Triene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request. We adhere to cGMP principles where applicable to support its use in research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.