Description

3,16β,17β-Tris(Trimethylsiloxy)Estra-1,3,5(10)-Triene is a high-purity, organosilicon-protected derivative of estra-1,3,5(10)-triene, a key steroid nucleus. This compound is valued as a crucial synthetic intermediate and protecting group reagent in advanced organic and medicinal chemistry. It is primarily required by research institutions and pharmaceutical development companies for the synthesis of novel steroid-based compounds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex steroid-based drug candidates and active pharmaceutical ingredients (APIs).
• Research Chemical: Used in academic and industrial R&D for studying steroid chemistry, receptor interactions, and metabolic pathways.
• Synthetic Reagent: Serves as a protected synthon in multi-step organic synthesis, leveraging the trimethylsiloxy groups for selective reactions.
• Hormone Analog Development: A precursor in the development of novel estrogen receptor modulators and other hormone analogs.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	3,16β,17β-Tris(Trimethylsiloxy)Estra-1,3,5(10)-Triene
CAS No.	57305-21-2
Molecular Formula	C27H48O3Si3
Molecular Weight	505.0 g/mol
Synonyms	Estra-1,3,5(10)-triene-3,16β,17β-triol, tris(trimethylsilyl) ether; 3,16β,17β-Tris-O-(trimethylsilyl)estra-1,3,5(10)-triene; Tris(trimethylsiloxy)estra-1,3,5(10)-triene; 3,16β,17β-Tris(trimethylsiloxy)estra-1,3,5(10)-triene; 3,16β,17β-Trihydroxyestra-1,3,5(10)-triene tris(trimethylsilyl) ether; TMS-protected estra-1,3,5(10)-triene triol.
EINECS	Contact for details

Quality Control

Our 3,16β,17β-Tris(Trimethylsiloxy)Estra-1,3,5(10)-Triene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.