Description

2-O,3-O,4-o-Tris(Trimethylsilyl)Ribaric Acid Bis(Trimethylsilyl) Ester is a highly functionalized, fully protected derivative of ribaric acid, designed for advanced synthetic applications. This compound is critical for researchers and manufacturers requiring precise control over reactivity and stereochemistry in complex molecule assembly. It serves as a key protected intermediate in the synthesis of nucleoside analogs, carbohydrate-based pharmaceuticals, and other fine chemicals where moisture-sensitive functional groups must be preserved.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Carbohydrate Chemistry: Used in the stereoselective synthesis of complex oligosaccharides, glycoconjugates, and glycomimetics.
• Protecting Group Strategy: The trimethylsilyl (TMS) groups provide robust protection for multiple hydroxyl functions, enabling selective deprotection and further functionalization.
• Process Chemistry Development: Employed in the scale-up and optimization of routes to high-value fine chemicals and active pharmaceutical ingredients (APIs).
• Chemical Biology Research: Serves as a precursor for labeled probes or modified sugars used in metabolic pathway studies.
• Material Science: Potential monomer or precursor for synthesizing specialized polymers with unique properties derived from sugar backbones.

Basic Information

Product Name	2-O,3-O,4-o-Tris(Trimethylsilyl)Ribaric Acid Bis(Trimethylsilyl) Ester
CAS No.	57197-34-9
Molecular Formula	C20H48O5Si5
Molecular Weight	537.04 g/mol
Synonyms	Ribaric Acid, 2,3,4-tris-O-(trimethylsilyl)-, bis(trimethylsilyl) ester; 2,3,4-Tris-O-trimethylsilylribaric Acid Bis(trimethylsilyl) Ester; Fully Silylated Ribaric Acid Ester; Pentakis(trimethylsilyl) Ribarate; Ribaric Acid Pentakis(trimethylsilyl) Ether; TMS-Ribarate; 57197-34-9; 2,3,4-Tri-O-trimethylsilyl-ribaric acid bis(trimethylsilyl) ester
EINECS	Contact for details

Quality Control

Our 2-O,3-O,4-o-Tris(Trimethylsilyl)Ribaric Acid Bis(Trimethylsilyl) Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications, and our quality commitment ensures reliable performance in your critical synthetic processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.