Description

(+)-Primaquine CAS NO 57152-56-4 is the dextrorotatory enantiomer of the antimalarial drug Primaquine, a critical compound in pharmaceutical research and development. Its primary value lies in its distinct biological activity profile compared to the racemic mixture or the (-)-enantiomer, enabling precise pharmacological studies and the development of targeted therapies. This high-purity chiral intermediate is essential for pharmaceutical manufacturers, research institutions, and contract development organizations focused on advanced antiparasitic drug discovery, chiral synthesis, and metabolic pathway investigation.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: Key chiral building block for the production of enantiomerically pure antimalarial drugs.
• Biochemical Research: Used in studies to understand the stereospecific metabolism, efficacy, and toxicity profiles of primaquine and related 8-aminoquinolines.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Chiral Catalyst & Ligand Development: Investigated for use in asymmetric synthesis due to its defined stereochemistry.
• Metabolite Studies: Employed in the synthesis and identification of specific active or toxic metabolites in pharmacokinetic research.
• Formulation Development: Used in pre-formulation studies for novel drug delivery systems targeting specific enantiomeric activity.

Basic Information

Product Name	(+)-Primaquine
CAS No.	57152-56-4
Molecular Formula	C15H21N3O
Molecular Weight	259.35 g/mol
Synonyms	(+)-Primaquine; (R)-Primaquine; Dextro-Primaquine; Primaquine enantiomer (+); 8-[(4-Amino-1-methylbutyl)amino]-6-methoxyquinoline (R)-enantiomer; NSC 133081; (8R)-Primaquine; WR-2975
EINECS	Contact for details

Quality Control

Our (+)-Primaquine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research and pharmaceutical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, ensuring data integrity for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual unknown impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.