Description

3-(Acetoxy)-7-Chloro-5-(2-Chlorophenyl)-1,3-Dihydro-2H-Pyrido[3,2-E]-1,4-Diazepin-2-One is a high-purity pharmaceutical intermediate of significant commercial importance. This compound is a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly within the benzodiazepine class, where it offers critical structural functionality. It is primarily required by pharmaceutical manufacturers and advanced R&D laboratories engaged in the development and production of therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of benzodiazepine-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the discovery and optimization of new central nervous system (CNS) targeting drugs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and process optimization studies for commercial API manufacturing routes.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	3-(Acetoxy)-7-Chloro-5-(2-Chlorophenyl)-1,3-Dihydro-2H-Pyrido[3,2-E]-1,4-Diazepin-2-One
CAS No.	57059-34-4
Molecular Formula	C16H11Cl2N3O3
Molecular Weight	364.18 g/mol
Synonyms	7-Chloro-5-(2-chlorophenyl)-3-(acetyloxy)-1,3-dihydro-2H-pyrido[3,2-e][1,4]diazepin-2-one; 3-Acetoxy-7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 3-Acetyloxy-7-chloro-5-(o-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 57059-34-4; A key intermediate for Lorazepam; Pyrido[3,2-e][1,4]diazepin-2-one derivative
EINECS	Contact for details

Quality Control

Our 3-(Acetoxy)-7-Chloro-5-(2-Chlorophenyl)-1,3-Dihydro-2H-Pyrido[3,2-E]-1,4-Diazepin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) documenting full specifications are available upon request, supporting compliance with cGMP and other relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.