Description

α-Ethynyl-2,2-Dimethyl-1,3-Dioxolane-4-Methanol Acetate is a specialized organic compound featuring a protected diol and an ethynyl functional group, making it a versatile chiral building block for complex organic synthesis. Its core value lies in providing a reactive handle for click chemistry and other coupling reactions while offering stereochemical control. This intermediate is primarily needed by research and development chemists in the pharmaceutical and fine chemical industries for the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of nucleoside analogs, antiviral agents, and other bioactive molecules.
• Agrochemical Synthesis: Building block for creating novel pesticides and herbicides with specific stereochemistry.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, flavors, and fragrances requiring precise molecular architecture.
• Academic & Industrial Research: Valuable reagent in methodological development for asymmetric synthesis and click chemistry applications.
• Material Science: Potential monomer or cross-linker in the development of polymers with tailored properties.
• Process Chemistry: Serves as an advanced intermediate in scalable, multi-step synthetic routes for commercial products.

Basic Information

Product Name	α-Ethynyl-2,2-Dimethyl-1,3-Dioxolane-4-Methanol Acetate
CAS No.	56666-75-2
Molecular Formula	C₁₀H₁₄O₄
Molecular Weight	198.22 g/mol
Synonyms	1,3-Dioxolane-4-methanol, 2,2-dimethyl-α-ethynyl-, acetate; (R)-(-)-2,2-Dimethyl-α-[(trimethylsilyl)ethynyl]-1,3-dioxolane-4-methanol Acetate (protected form); Acetate of α-Ethynyl-2,2-dimethyl-1,3-dioxolane-4-methanol; Solketal ethynyl acetate; Chiral acetylene derivative of isopropylidene glycerol; 4-(Acetoxymethyl)-2,2-dimethyl-α-ethynyl-1,3-dioxolane
EINECS	Contact for details

Quality Control

Our α-Ethynyl-2,2-Dimethyl-1,3-Dioxolane-4-Methanol Acetate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided to guarantee consistent quality, identity, and purity for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.