Description

(+)-Diethyl 2,3-o-Isopropylidene-D-Tartrate is a high-purity chiral building block and protecting group reagent essential for asymmetric synthesis. This compound is valued for its role in constructing complex molecules with precise stereochemistry, enabling the production of high-value intermediates in regulated industries. It is primarily required by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and fine chemical sectors for the development of active pharmaceutical ingredients (APIs), catalysts, and specialty chemicals.

Application

• Chiral Auxiliary and Ligand Synthesis: A key precursor for synthesizing chiral ligands used in asymmetric catalysis, such as Sharpless dihydroxylation catalysts.
• Pharmaceutical Intermediate: Critical building block in the multi-step synthesis of complex, stereochemically defined active pharmaceutical ingredients (APIs).
• Fine Chemical Production: Used in the manufacture of specialty chemicals, flavors, and fragrances where specific enantiomeric purity is required.
• Agrochemical Research: Employed in developing chiral pesticides and herbicides with enhanced efficacy and environmental profiles.
• Academic & Industrial R&D: Serves as a standard reagent in methodological development for new asymmetric transformations and synthetic routes.
• Protecting Group Chemistry: The isopropylidene group effectively protects vicinal diols, a crucial step in complex multi-functional molecule synthesis.

Basic Information

Product Name	(+)-Diethyl 2,3-o-Isopropylidene-D-Tartrate
CAS No.	56543-05-6
Molecular Formula	C12H20O6
Molecular Weight	260.28 g/mol
Synonyms	D-(-)-Diethyl 2,3-O-Isopropylidene Tartrate; (2R,3R)-Diethyl 2,3-O-[(1-Methylethylidene)]-D-Tartrate; Diethyl (R,R)-2,3-O-Isopropylidene Tartrate; Diethyl Acetonide-D-Tartrate; Diethyl D-(-)-2,3-O-Isopropylidene Tartrate; Diethyl (4R,5R)-2,2-Dimethyl-1,3-dioxolane-4,5-dicarboxylate; DET; DIPT
EINECS	Contact for details

Quality Control

Our (+)-Diethyl 2,3-o-Isopropylidene-D-Tartrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and enantiomeric purity, meeting the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) and optical rotation values are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation [α]20/D	-18.0° to -22.0° (c=1 in CHCl3)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.