Description

tert-Butyldimethylsilyl Cyanide is a versatile organosilicon reagent primarily used as a cyanide source and protecting group agent in organic synthesis. This compound is valued for its ability to introduce the cyano group under mild conditions and for its role in protecting sensitive functional groups during complex multi-step reactions. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries, facilitating the production of active pharmaceutical ingredients (APIs), fine chemicals, and novel organic compounds.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for the cyanation step in the production of various active pharmaceutical ingredients (APIs) and drug candidates.
• Nitrile & Cyanohydrin Formation: Used to efficiently convert carbonyl compounds (aldehydes, ketones) into corresponding nitriles and cyanohydrins.
• Silyl Protecting Group Chemistry: Serves as a tert-butyldimethylsilyl (TBDMS) protecting group donor for alcohols, phenols, and other nucleophiles.
• Agrochemical Manufacturing: Employed in the synthesis of herbicides, fungicides, and insecticides that contain nitrile or cyano functionalities.
• Fine Chemical & Specialty Chemical Production: Integral to the synthesis of complex molecules, dyes, and photoinitiators.
• Academic & R&D Laboratories: A staple reagent for methodological development and exploratory synthesis in organic chemistry research.
• Material Science Precursor: Used in the preparation of silicon-containing polymers and advanced organic materials.

Basic Information

Product Name	tert-Butyldimethylsilyl Cyanide
CAS No.	56522-24-8
Molecular Formula	C7H15NSi
Molecular Weight	141.29 g/mol
Synonyms	TBDMS-CN; (tert-Butyldimethylsilyl)cyanide; Cyanotert-butyldimethylsilane; tert-Butyl(dimethyl)silyl Cyanide; TBDMSCN; NSC 334365; t-Butyldimethylsilyl Cyanide; Cyanotrimethylsilane, tert-butyl-
EINECS	Contact for details

Quality Control

Our tert-Butyldimethylsilyl Cyanide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.