Description

2-Hydroxylomustine is a chemically modified derivative of the alkylating agent lomustine, designed for research and advanced pharmaceutical synthesis. This compound matters as a key intermediate for developing novel therapeutic agents, particularly in oncology research, due to its potential for targeted drug delivery and reduced systemic toxicity. It is needed by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on anticancer drug development and prodrug synthesis.

Application

• Pharmaceutical Intermediate: Primary use as a building block in the synthesis of novel chemotherapeutic agents and targeted cancer therapies.
• Oncology Research: Critical reagent in preclinical studies investigating the structure-activity relationships (SAR) of nitrosourea-based alkylating agents.
• Prodrug Development: Utilized in the design and synthesis of prodrugs aimed at improving the selectivity and bioavailability of anticancer compounds.
• Bioconjugation: Serves as a functional handle for conjugating cytotoxic payloads to antibodies, peptides, or other targeting molecules in antibody-drug conjugate (ADC) research.
• Mechanistic Studies: Used in biochemical and pharmacological research to study DNA alkylation mechanisms and cellular resistance pathways.
• Reference Standard: Sourced for use as an analytical standard in quality control (QC) and method development for pharmaceutical manufacturing.

Basic Information

Product Name	2-Hydroxylomustine
CAS No.	56323-43-4
Molecular Formula	C9H16ClN3O3
Molecular Weight	249.70 g/mol
Synonyms	1-(2-Chloroethyl)-3-(2-hydroxycyclohexyl)-1-nitrosourea; 2-Hydroxy-CCNU; 2'-Hydroxylomustine; NSC 290205; 1-Nitroso-1-(2-chloroethyl)-3-(trans-2-hydroxycyclohexyl)urea; trans-1-(2-Chloroethyl)-3-(2-hydroxycyclohexyl)-1-nitrosourea; Lomustine, 2'-hydroxy-
EINECS	Contact for details

Quality Control

Our 2-Hydroxylomustine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.