Description

3'-[[Bis(2-Chloroethyl)Amino]Methyl]-4'-Methoxyacetanilide is a specialized nitrogen mustard derivative with a complex molecular structure designed for targeted reactivity. This compound matters for its role as a key synthetic intermediate in advanced pharmaceutical research, particularly in the development of novel chemotherapeutic agents and targeted drug conjugates. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors who are engaged in oncology drug discovery and the synthesis of bioactive molecules.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of experimental alkylating agents and anticancer prodrugs.
• Oncology Research: Used in academic and industrial laboratories to develop novel chemotherapeutic compounds targeting specific cellular pathways.
• Bioconjugation: Serves as a linker or payload in the development of antibody-drug conjugates (ADCs) and other targeted therapies.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of nitrogen mustard-based drugs.
• Process Chemistry: Used in scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Biochemical Tool: Acts as a research chemical for studying DNA alkylation mechanisms and cellular response to genotoxic stress.

Basic Information

Product Name	3'-[[Bis(2-Chloroethyl)Amino]Methyl]-4'-Methoxyacetanilide
CAS No.	56288-29-0
Molecular Formula	C14H20Cl2N2O2
Molecular Weight	319.23 g/mol
Synonyms	4'-Methoxy-3'-[[bis(2-chloroethyl)amino]methyl]acetanilide; NSC 176319; 1-(4-Methoxyphenyl)-2-[bis(2-chloroethyl)amino]acetamide; Acetamide, N-[4-methoxy-3-[[bis(2-chloroethyl)amino]methyl]phenyl]-; 3'-(Bis(2-chloroethyl)aminomethyl)-4'-methoxyacetanilide
EINECS	Contact for details

Quality Control

Our 3'-[[Bis(2-Chloroethyl)Amino]Methyl]-4'-Methoxyacetanilide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.