Description

n-(4-Hydroxybenzoyl)Glycine Bis(Trimethylsilyl) Deriv. is a silylated derivative of a key glycine conjugate, designed to enhance volatility and stability for advanced analytical and synthetic processes. This compound is crucial for researchers and manufacturers requiring precise derivatization to enable gas chromatographic analysis or to protect sensitive functional groups during complex chemical synthesis. It serves as a vital intermediate and analytical standard in pharmaceutical research, agrochemical development, and advanced material science.

Application

• GC-MS Analysis: Used as a derivatization agent to improve the volatility and detectability of carboxylic acids and phenolic compounds in complex biological or environmental matrices.
• Pharmaceutical Intermediate: Serves as a protected synthetic building block in the multi-step synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Metabolite Profiling: Essential for the preparation and identification of metabolic conjugates, such as hippuric acid derivatives, in metabolomics and pharmacokinetic studies.
• Agrochemical Research: Employed in the synthesis and analysis of novel herbicide or pesticide compounds that utilize glycine or benzoyl-based chemistries.
• Protecting Group Chemistry: The bis(trimethylsilyl) groups effectively protect hydroxyl and carboxyl functionalities during sensitive organic synthesis reactions.
• Reference Standard: Provides a high-purity analytical standard for method development and quality control in laboratories.

Basic Information

Item	Detail
Product Name	n-(4-Hydroxybenzoyl)Glycine Bis(Trimethylsilyl) Deriv.
CAS No.	56272-90-3
Molecular Formula	C15H25NO4Si2
Molecular Weight	339.54 g/mol
Synonyms	Bis(trimethylsilyl) N-(4-hydroxybenzoyl)glycinate; Hippuric Acid, 4-Hydroxy-, Bis(trimethylsilyl) Derivative; N-(4-Hydroxybenzoyl)glycine bis(trimethylsilyl) ester; TMS Derivative of 4-Hydroxyhippuric Acid; 4-Hydroxyhippuric Acid Bis(trimethylsilyl) Ester; Glycine, N-(4-hydroxybenzoyl)-, bis(trimethylsilyl) ester; 56272-90-3; 4-Carboxymethylaminocarbonylphenyl Trimethylsilyl Ether
EINECS	Contact for details

Quality Control

Our n-(4-Hydroxybenzoyl)Glycine Bis(Trimethylsilyl) Deriv. is produced under stringent conditions to ensure high chemical purity and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to verify identity and purity. Certificates of Analysis (COA) documenting all relevant specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can compromise product integrity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.