Description

1-O,2-O,3-O,4-o-Tetrakis(Trimethylsilyl)-D-Ribopyranose is a fully protected derivative of D-ribose, a fundamental sugar building block. This compound is critically important as a key synthetic intermediate in the production of nucleosides, nucleotides, and other complex bioactive molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of antiviral drugs, modified oligonucleotides, and carbohydrate-based therapeutics.

Application

• Nucleoside/Nucleotide Synthesis: A crucial protected intermediate for the controlled synthesis of ribonucleoside analogs and their phosphoramidites.
• Antiviral & Anticancer Drug Development: Used in the research and production of modified nucleosides that act as therapeutic agents.
• Oligonucleotide & siRNA Manufacturing: Serves as a building block for solid-phase synthesis of RNA fragments and small interfering RNA (siRNA).
• Carbohydrate Chemistry Research: Enables selective functionalization and glycosylation reactions in complex sugar synthesis.
• Labeled Compound Production: Used as a precursor for synthesizing isotopically labeled (e.g., 13C, 2H) sugars for metabolic studies.
• Glycoconjugate Synthesis: A starting material for creating glycopeptides, glycolipids, and other biologically active conjugates.

Basic Information

Product Name	1-O,2-O,3-O,4-o-Tetrakis(Trimethylsilyl)-D-Ribopyranose
CAS No.	56271-70-6
Molecular Formula	C20H48O5Si4
Molecular Weight	504.92 g/mol
Synonyms	D-Ribopyranose, 1,2,3,4-tetrakis-O-(trimethylsilyl)-; Tetrakis-O-trimethylsilyl-D-ribopyranose; 1,2,3,4-Tetra-O-trimethylsilyl-D-ribopyranose; Per-O-trimethylsilyl-D-ribose; TMS-D-ribose; Fully protected D-ribose; D-Ribose, tetrakis(trimethylsilyl) ether
EINECS	Contact for details

Quality Control

Our 1-O,2-O,3-O,4-o-Tetrakis(Trimethylsilyl)-D-Ribopyranose is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP and ISO standards for pharmaceutical intermediates, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent hydrolysis and degradation. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.