Description

3β,6-Bis[(Trimethylsilyl)Oxy]-5α-Androstan-5-Ol is a high-purity, organosilicon-protected steroid derivative, serving as a crucial synthetic intermediate in advanced pharmaceutical research and development. Its value lies in providing a stable, protected scaffold for the targeted synthesis of complex steroid-based molecules, enabling precise chemical modifications. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries focused on developing novel therapeutic agents, particularly in endocrinology and metabolic disease research.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of novel steroid-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of hormone analogs.
• Fine Chemical Synthesis: Intermediate for producing specialized steroidal compounds used in biochemical assays and diagnostic reagents.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex steroid molecules.

Basic Information

Product Name	3β,6-Bis[(Trimethylsilyl)Oxy]-5α-Androstan-5-Ol
CAS No.	56248-35-2
Molecular Formula	C25H46O3Si2
Molecular Weight	450.81 g/mol
Synonyms	5α-Androstan-5-ol, 3β,6-bis[(trimethylsilyl)oxy]-; 3β,6β-Bis(trimethylsiloxy)-5α-androstan-5-ol; Androstane-3β,6β-diol, 5α-, bis(trimethylsilyl) ether; 5α-Androstane-3β,6β-diol bis(trimethylsilyl) ether; 3β,6β-Di-O-trimethylsilyl-5α-androstan-5-ol; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 3β,6-Bis[(Trimethylsilyl)Oxy]-5α-Androstan-5-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to confirm identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We adhere to cGMP principles for pharmaceutical intermediates, ensuring traceability and documentation for regulated applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and stored in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.