Description

1-(2-Chloroethyl)-3-(4-Hydroxycyclohexyl)-1-Nitroso-Urea is a specialized nitrosourea derivative of significant interest in advanced chemical synthesis and pharmaceutical research. This compound serves as a critical intermediate for developing novel therapeutic agents, particularly in oncology research, due to its unique alkylating properties. It is primarily utilized by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in the creation of targeted cancer therapies and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel alkylating chemotherapeutic agents and targeted cancer drugs.
• Oncology Research: Used in biochemical and pharmacological studies to investigate DNA alkylation mechanisms and develop new treatment modalities.
• Medicinal Chemistry: Serves as a precursor for structure-activity relationship (SAR) studies to optimize drug potency and reduce side effects.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses requiring specific nitrosourea functionality for specialized applications.
• Bioconjugation: Potential use in developing antibody-drug conjugates (ADCs) and other targeted delivery systems due to its reactive chloroethyl group.
• Academic Research: Utilized in university and institutional labs for studying chemical carcinogenesis and DNA repair mechanisms.

Basic Information

Product Name	1-(2-Chloroethyl)-3-(4-Hydroxycyclohexyl)-1-Nitroso-Urea
CAS No.	56239-24-8
Molecular Formula	C9H16ClN3O3
Molecular Weight	249.70 g/mol
Synonyms	1-(2-Chloroethyl)-3-(4-hydroxycyclohexyl)-1-nitrosourea; 3-(4-Hydroxycyclohexyl)-1-(2-chloroethyl)-1-nitrosourea; NSC 172112; Nitrosourea derivative C9H16ClN3O3; 1-Nitroso-1-(2-chloroethyl)-3-(4-hydroxycyclohexyl)urea; Hydroxy-CCNU (analog); Cyclohexyl Hydroxy Nitrosourea Derivative
EINECS	Contact for details

Quality Control

Our 1-(2-Chloroethyl)-3-(4-Hydroxycyclohexyl)-1-Nitroso-Urea is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets the exacting standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, identity, and all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.