Description

1-O,2-O,3-O,5-o-Tetrakis(trimethylsilyl)-6-deoxy-β-L-mannofuranose is a highly functionalized, protected carbohydrate derivative, specifically a per-silylated deoxy sugar. This compound is a critical synthetic intermediate, valued for its role in constructing complex oligosaccharides and nucleoside analogs where precise stereochemistry and protecting group strategy are paramount. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced carbohydrate chemistry, medicinal chemistry, and the development of novel therapeutics and diagnostics.

Application

• Glycosylation Reactions: Serves as a key glycosyl donor or acceptor in the stereoselective synthesis of complex oligosaccharides and glycoconjugates.
• Nucleoside & Nucleotide Analog Synthesis: Used as a chiral building block for the preparation of modified nucleosides with potential antiviral or anticancer activity.
• Medicinal Chemistry & Drug Discovery: Acts as a versatile intermediate for creating sugar-modified pharmacophores and prodrugs.
• Chemical Biology Probes: Employed in the synthesis of labeled carbohydrates for studying biological recognition and metabolic pathways.
• Chiral Auxiliary or Ligand Precursor: The protected sugar scaffold can be modified for use in asymmetric synthesis.
• Academic & Industrial R&D: Essential for fundamental research in carbohydrate chemistry and applied development in biopharmaceuticals.

Basic Information

Product Name	1-O,2-O,3-O,5-o-Tetrakis(trimethylsilyl)-6-deoxy-β-L-mannofuranose
CAS No.	56227-37-3
Molecular Formula	C22H52O5Si4
Molecular Weight	509.0 g/mol
Synonyms	6-Deoxy-β-L-mannofuranose, 1,2,3,5-tetrakis-O-(trimethylsilyl)-; 1,2,3,5-Tetra-O-trimethylsilyl-6-deoxy-β-L-mannofuranose; β-L-6-Deoxymannofuranose tetrakis(trimethylsilyl) ether; Per-O-trimethylsilylated 6-deoxy-β-L-mannose; TMS-protected 6-deoxy-β-L-mannofuranose; 6-Deoxy-1,2,3,5-tetra-O-trimethylsilyl-β-L-mannofuranose
EINECS	Contact for details

Quality Control

Every batch of 1-O,2-O,3-O,5-o-Tetrakis(trimethylsilyl)-6-deoxy-β-L-mannofuranose is produced and controlled under a strict quality management system. We employ advanced analytical techniques including NMR (¹H, ¹³C), HPLC, and GC to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95%
Water Content (KF)	≤ 0.5%
Specific Rotation [α]	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.