Description

Methyl 2-O,3-O,5-o-Tris(trimethylsilyl)-6-deoxy-α-L-galactofuranoside is a specialized, high-purity silylated carbohydrate derivative, primarily used as a crucial synthetic intermediate and protecting group reagent in advanced organic synthesis. Its value lies in enabling complex, multi-step syntheses of nucleosides, modified sugars, and other bioactive molecules by providing selective protection for hydroxyl groups. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise control over stereochemistry and functional group manipulation.

Application

• Key Intermediate in Nucleoside Synthesis: Used in the preparation of modified nucleosides and nucleotides for antiviral and anticancer drug discovery.
• Building Block for Glycochemistry: Serves as a protected galactofuranosyl donor for the synthesis of complex oligosaccharides and glycoconjugates.
• Chiral Pool Reagent: Utilized as a chiral starting material or auxiliary in asymmetric synthesis due to its defined α-L configuration.
• Protecting Group Strategy: The trimethylsilyl (TMS) groups provide orthogonal protection that can be selectively removed under mild conditions.
• Pharmaceutical R&D: Employed in the research and process development of new active pharmaceutical ingredients (APIs), particularly those with carbohydrate motifs.
• Fine Chemical Production: Acts as a precursor for the manufacture of high-value specialty chemicals and research biochemicals.

Basic Information

Item	Detail
Product Name	Methyl 2-O,3-O,5-o-Tris(trimethylsilyl)-6-deoxy-α-L-galactofuranoside
CAS No.	56227-31-7
Molecular Formula	C16H38O5Si3
Molecular Weight	394.73 g/mol
Synonyms	Methyl 2,3,5-Tri-O-trimethylsilyl-6-deoxy-α-L-galactofuranoside; 6-Deoxy-α-L-galactofuranoside, methyl 2,3,5-tris-O-(trimethylsilyl)-; Methyl 6-deoxy-2,3,5-tri-O-trimethylsilyl-α-L-galactofuranoside; α-L-Galactofuranoside, methyl 6-deoxy-2,3,5-tris-O-(trimethylsilyl)-; TMS-protected methyl 6-deoxy-α-L-galactofuranoside; Methyl α-L-6-deoxygalactofuranoside 2,3,5-tris(trimethylsilyl) ether
EINECS	Contact for details

Quality Control

Every batch of Methyl 2-O,3-O,5-o-Tris(trimethylsilyl)-6-deoxy-α-L-galactofuranoside is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from NMR, HPLC, and other relevant spectroscopic methods. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions, such as in a glovebox or under an inert atmosphere (nitrogen/argon), to prevent decomposition. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (NMR)	Conforms to structure (¹H NMR, ¹³C NMR)
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.