Description

(9E,13E,15S)-9-(Methoxyimino)-15-(Trimethylsiloxy)Prosta-10,13-Dien-1-Oic Acid Trimethylsilyl Ester is a key synthetic intermediate in the production of prostaglandin analogs. This compound is of significant value for its role in constructing complex, biologically active molecules with precise stereochemistry. It is primarily needed by pharmaceutical R&D and manufacturing teams focused on developing therapeutics for cardiovascular, ocular, and inflammatory conditions.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of prostaglandin-based active pharmaceutical ingredients (APIs).
• Ophthalmic Drug Development: Used in research and production of prostaglandin analogs for glaucoma treatment (e.g., Latanoprost, Travoprost precursors).
• Cardiovascular Research: Serves as a precursor in studies targeting vasodilation and platelet aggregation.
• Chemical Synthesis: Utilized in advanced organic synthesis for introducing the protected prostanoid backbone.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for prostaglandin derivatives.
• Academic & Contract Research: Used in university and CRO laboratories for medicinal chemistry and pharmacological studies.

Basic Information

Product Name	(9E,13E,15S)-9-(Methoxyimino)-15-(Trimethylsiloxy)Prosta-10,13-Dien-1-Oic Acid Trimethylsilyl Ester
CAS No.	56227-28-2
Molecular Formula	C27H49NO4Si2
Molecular Weight	507.86 g/mol
Synonyms	9-(Methoxyimino)-15-(trimethylsiloxy)prosta-10,13-dien-1-oic acid trimethylsilyl ester; Prostaglandin F2α trimethylsilyl ether oxime methyl ether; PGF2α TMS ether oxime methyl ether; 9-ONe,15-OTMS Prostaglandin intermediate; (9E,13E,15S)-9-(Methoxyimino)-15-(trimethylsilyloxy)prosta-10,13-dien-1-oic acid trimethylsilyl ester; 15(S)-TMS-9-ONe Prostaglandin derivative
EINECS	Contact for details

Quality Control

Our production of this high-value pharmaceutical intermediate adheres to strict quality management systems. Each batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Assay (by HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.