Description

[α-(Acetylamino)-4-(Trimethylsiloxy)Phenethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a sophisticated organosilicon-protected phosphonate derivative, serving as a critical synthetic intermediate. Its value lies in providing a masked, stable form of a reactive phosphonic acid group, enabling precise chemical transformations under mild conditions. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and advanced materials science who require high-purity, specialized building blocks.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting bone metabolism or requiring phosphonate bioisosteres.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and plant growth regulators containing phosphonate moieties.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized phosphonate-based ligands used in asymmetric catalysis and metal complexation.
• Peptide Mimetics and Prodrug Development: The protected phosphonic acid group is valuable for constructing phosphonopeptides and designing prodrug strategies to enhance bioavailability.
• Surface Modification Agent: Potential use in modifying material surfaces (e.g., silica, metals) to introduce specific functional groups for adhesion or biocompatibility.
• Chemical Biology Research: Tool compound for studying enzyme inhibition, signal transduction pathways, and developing activity-based probes.

Basic Information

Product Name	[α-(Acetylamino)-4-(Trimethylsiloxy)Phenethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	56227-25-9
Molecular Formula	C20H38NO5PSi3
Molecular Weight	487.73 g/mol
Synonyms	N-[2-[4-(Trimethylsilyloxy)phenyl]-1-[(bis(trimethylsilyl)oxy)phosphinyl]ethyl]acetamide; Phosphonic acid, P-[2-(acetylamino)-2-[4-(trimethylsiloxy)phenyl]ethyl]-, bis(trimethylsilyl) ester; Acetamide, N-[2-[4-(trimethylsilyloxy)phenyl]-1-[(bis(trimethylsilyl)oxy)phosphinyl]ethyl]-; TMS-Protected Phosphonate Ester; α-Acetamido-4-(trimethylsiloxy)phenethylphosphonic Acid Bis-TMS Ester
EINECS	Contact for details

Quality Control

Every batch of [α-(Acetylamino)-4-(Trimethylsiloxy)Phenethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is manufactured and analyzed under strict quality management protocols. We ensure compliance with relevant industry standards for fine chemical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.