Description

Di-o-Methylbis-o-(Trimethylsilyl)-D-Erythro-Hex-2-Enonic Acid γ-Lactone is a sophisticated organosilicon-protected carbohydrate derivative, specifically a silylated lactone of a modified hexose sugar. This compound serves as a critical chiral building block and advanced synthetic intermediate in the production of complex organic molecules, enabling precise stereochemical control. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions engaged in the synthesis of nucleoside analogs, antiviral agents, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel nucleoside analogs and antiviral drugs.
• Fine Chemical Synthesis: Advanced building block for constructing complex, stereochemically defined natural products and their derivatives.
• Glycochemistry Research: Protected sugar lactone used in the study and synthesis of modified carbohydrates and glycoconjugates.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of high-value active pharmaceutical ingredients (APIs).
• Asymmetric Catalysis Substrate: Used as a test substrate or chiral template in the development of new asymmetric synthetic methodologies.
• Bioconjugation Chemistry: Potential intermediate for creating chemically modified biomolecules for diagnostic or therapeutic applications.

Basic Information

Product Name	Di-o-Methylbis-o-(Trimethylsilyl)-D-Erythro-Hex-2-Enonic Acid γ-Lactone
CAS No.	56211-35-9
Molecular Formula	C16H32O6Si2
Molecular Weight	376.60 g/mol
Synonyms	2,3,4,5-Tetra-O-trimethylsilyl-D-glucono-1,5-lactone; D-Glucono-1,5-lactone, 2,3,4,5-tetrakis-O-(trimethylsilyl)-; Tetrakis(trimethylsilyl) D-gluconolactone; 2,3,4,5-Tetrakis-O-(trimethylsilyl)-D-glucono-1,5-lactone; Silylated Gluconolactone; Protected Hexonolactone; TMS-Gluconolactone; CAS 56211-35-9
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support development and commercial projects requiring compliance with ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.