Description

3-o-Methyl-2-O,4-O,5-o-Tris(Trimethylsilyl)-D-Ribose o-Methyl Oxime is a sophisticated, protected ribose derivative, a key synthetic intermediate in nucleoside and oligonucleotide chemistry. Its primary value lies in enabling the precise construction of complex sugar backbones for research and pharmaceutical development. This high-purity building block is essential for scientists and manufacturers in the fields of antiviral drug discovery, mRNA technology, and oligonucleotide synthesis, where reliable access to structurally defined intermediates is critical.

Application

• Nucleoside & Nucleotide Analog Synthesis: A crucial protected intermediate for constructing modified nucleosides used in antiviral and anticancer therapeutics.
• Oligonucleotide & mRNA Production: Serves as a building block in solid-phase synthesis for research-grade and therapeutic oligonucleotides, including siRNA and mRNA components.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the discovery and development of novel RNA-targeting drugs and prodrugs.
• Carbohydrate Chemistry: A valuable reagent for the study and synthesis of complex, modified sugar molecules and glycoconjugates.
• Process Chemistry & Scale-Up: Supplied for route development and optimization in pilot-scale and commercial manufacturing of active pharmaceutical ingredients (APIs).
• Bioconjugation & Probe Development: Can be utilized to create labeled nucleotides or sugar-based probes for diagnostic and biochemical applications.

Basic Information

Product Name	3-o-Methyl-2-O,4-O,5-o-Tris(Trimethylsilyl)-D-Ribose o-Methyl Oxime
CAS No.	56196-11-3
Molecular Formula	C17H41NO5Si3
Molecular Weight	435.84 g/mol
Synonyms	1,2-O-Isopropylidene-3-O-methyl-5-O-(trimethylsilyl)-α-D-ribofuranose Oxime; 3-O-Methyl-1,2-O-isopropylidene-5-O-(trimethylsilyl)-α-D-ribofuranose Oxime; 3-O-Methyl-1,2-O-isopropylidene-5-O-TMS-α-D-ribofuranose Oxime; Protected D-Ribose Oxime Derivative; TMS-protected Ribose Oxime; D-Ribose, 3-O-methyl-1,2-O-(1-methylethylidene)-5-O-(trimethylsilyl)-, oxime; 56196-11-3; Nucleoside Synthesis Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict in-process controls to ensure batch-to-batch consistency and high chemical purity. Each lot is fully characterized and tested using advanced analytical techniques including HPLC, NMR, and GC. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.