Description

2-o-Methyl-3-O,4-O,5-o-Tris(Trimethylsilyl)-D-Ribose o-Methyl Oxime is a sophisticated, protected ribose derivative, a key building block in nucleoside and oligonucleotide synthesis. Its value lies in providing a reactive oxime group and silyl-protected hydroxyls, enabling precise and efficient chemical transformations under controlled conditions. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, particularly for creating antiviral and anticancer agents, as well as in advanced biochemical research.

Application

• Nucleoside Analog Synthesis: A critical precursor for the chemical synthesis of modified nucleosides used in therapeutic applications.
• Oligonucleotide Production: Serves as a protected monomer or intermediate in the solid-phase synthesis of antisense oligonucleotides and siRNA.
• Pharmaceutical Intermediates: Used in the research and development of prodrugs and active pharmaceutical ingredients (APIs) targeting viral and oncological diseases.
• Bioconjugation Chemistry: The oxime functionality allows for site-specific conjugation with aldehydes and ketones, useful in linker chemistry and probe development.
• Carbohydrate Chemistry Research: A valuable tool for studying glycosylation reactions and synthesizing complex sugar derivatives.
• Diagnostic Reagent Development: Employed in the creation of labeled probes and reagents for molecular diagnostics.

Basic Information

Item	Detail
Product Name	2-o-Methyl-3-O,4-O,5-o-Tris(Trimethylsilyl)-D-Ribose o-Methyl Oxime
CAS No.	56196-10-2
Molecular Formula	C17H41NO5Si3
Molecular Weight	435.86 g/mol
Synonyms	1,2-Dideoxy-1-(methoxyimino)-3,4,5-tris-O-(trimethylsilyl)-D-ribose; D-Ribose, 2-deoxy-1-(methoxyimino)-, 3,4,5-tris-O-(trimethylsilyl)-; 2-Deoxy-1-methoxyimino-3,4,5-tris-O-trimethylsilyl-D-ribose; 1-Methoxyimino-2-deoxy-3,4,5-tris-O-trimethylsilyl-D-ribose; Protected D-Ribose Oxime; TMS-protected Ribose Oxime; Nucleoside Synthesis Intermediate
EINECS	Contact for details

Quality Control

Every batch of our 2-o-Methyl-3-O,4-O,5-o-Tris(Trimethylsilyl)-D-Ribose o-Methyl Oxime is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR, and GC to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment, supporting your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccated environment to prevent degradation. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.