Description

2-O,3-O,4-O,5-o-Tetrakis(Trimethylsilyl)-D-Ribose o-Methyl Oxime is a highly functionalized, protected ribose derivative, a critical intermediate in sophisticated organic synthesis. Its value lies in providing a versatile, multi-protected sugar scaffold that enables precise, stepwise chemical modifications under controlled conditions. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for the synthesis of nucleoside analogs, antiviral agents, and complex carbohydrate-based therapeutics.

Application

• Key Intermediate in Nucleoside Synthesis: Serves as a protected precursor for the development of modified nucleosides and nucleotides used in antiviral and anticancer drug candidates.
• Carbohydrate Chemistry Research: Used in academic and industrial R&D for studying glycosylation reactions and constructing complex oligosaccharide structures.
• Pharmaceutical Process Development: Employed in the scalable synthesis of active pharmaceutical ingredients (APIs) where a protected ribose moiety is required.
• Synthesis of Labeled Compounds: Acts as a starting material for the preparation of isotopically labeled (e.g., 13C, 2H) sugars for metabolic and pharmacokinetic studies.
• Protecting Group Strategy: The trimethylsilyl (TMS) groups allow for selective deprotection, enabling complex, multi-step synthetic routes in medicinal chemistry.

Basic Information

Product Name	2-O,3-O,4-O,5-o-Tetrakis(Trimethylsilyl)-D-Ribose o-Methyl Oxime
CAS No.	56196-08-8
Molecular Formula	C17H41NO5Si4
Molecular Weight	463.88 g/mol
Synonyms	D-Ribose, O-methyloxime, 2,3,4,5-tetrakis-O-(trimethylsilyl)-; 2,3,4,5-Tetra-O-trimethylsilyl-D-ribose O-methyloxime; Tetrakis(trimethylsilyl)-D-ribose methyloxime; D-Ribose O-methyloxime, 2,3,4,5-tetrakis-O-(trimethylsilyl)-; 56196-08-8; Protected D-ribose methyloxime; TMS-protected ribose oxime
EINECS	Contact for details

Quality Control

Our 2-O,3-O,4-O,5-o-Tetrakis(Trimethylsilyl)-D-Ribose o-Methyl Oxime is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.